The film follows Legendary undercover DEA agent Charlie Mayough (Liam Neeson) who has suddenly lost his nerves of steel. On the verge of a career-induced mental breakdown, and in complete fear of trigger-happy Mafia leader Fulvio Nesstra (Oliver Platt), Charlie seeks psychiatric help and finds himself relying on the support of an unstable therapy group and nurse Judy (Sandra Bullock) just to get through his work.