Song One is a romantic drama in which Franny Ellis (Anne Hathaway) tries to revive her brother Henry (Ben Rosenfield) who is in a coma after a car accident by seeking out his favorite musican James Forester (Johnny Flynn) and convinces him to play by her brother's bedside. Gradually a strong romantic connection between Franny and the musican blooms in the most adverse situations. Love smiles. Henry awakens.