Two brutal criminals brothers Seth and Richie Gecko are heading to Mexico for a reformed life, during which they kidnap and hold hostage widowed preacher Jacob Fuller and his two children to easily pass the border. Once south of the border, the notorious Gecko brothers stop at the Titty Twister bar to rendezvous for a money drops, being unaware this is actually the deadly lair of a bloodthirsty gang of vampires. Becoming the preys for a force they have never coped with before, the Geckos now must join forces with their hostages to get away from those monstrous creatures.